The basics
Understanding Spravato Treatment
Spravato (esketamine) is an FDA-approved nasal spray for eligible adults with treatment-resistant depression. It's administered under medical supervision as part of a complete, ongoing treatment plan.
- FDA-approved specifically for treatment-resistant depression in eligible adults.
- Delivered as a nasal spray in a monitored clinical setting.
- Acts on the brain's glutamate system, a different mechanism than traditional antidepressants.
- Combined with therapy and follow-up care for the best results.
Who it helps
Who Can Benefit From Spravato Treatment
Spravato treatment may be an option for eligible adults with treatment-resistant depression, including those who:
Schedule an AppointmentEligibility is determined through a full evaluation, not a quick screening. Your psychiatrist will walk through your treatment history with you before recommending Spravato.
Benefits
Benefits of Spravato Treatment
Spravato has shown promising results in clinical studies for adults with treatment-resistant depression.
Schedule an AppointmentThese benefits build over the course of treatment rather than a single session. Your psychiatrist will track your response and adjust your plan as you progress.
Step by step
How Spravato Treatment Works
Initial Evaluation
Your psychiatrist reviews your mental health history and prior treatments to confirm Spravato is the right fit for you.
Induction Phase
Treatment typically starts with twice-weekly sessions for the first four weeks.
Maintenance Phase
Sessions then shift to once-weekly or biweekly visits based on how you're responding.
Monitored Recovery
After each dose, you're monitored for about two hours to watch for side effects like dizziness or changes in blood pressure.
Your first visit
What to Expect During Your First Spravato Visit
Your first visit starts with a full review of your mental health history and previous treatments, followed by a conversation about how Spravato fits into your overall care plan. If you and your psychiatrist decide to move forward, your first dose is administered under direct supervision in a controlled setting.
You'll then be monitored for about two hours afterward to make sure any side effects are managed safely before you leave. From there, we'll schedule your ongoing sessions and build out the rest of your treatment plan together.

Questions
FAQs on Spravato Treatment
What are the side effects of Spravato?
−Common side effects include dissociation, dizziness, nausea, sedation, and a temporary rise in blood pressure. These effects are typically short-lived and closely monitored during the two-hour observation period after each session.




